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In humans, the selenoprotein family comprises a diverse group of proteins, including the glutathione peroxidases (GPX1 to GPX4 and GPX6), the thioredoxin reductases (TXNRD1 and TXNRD2), and thioredoxin–glutathione reductase (TXNRD3)
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This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy
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