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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

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In adipose tissue, Roberti, Fernández, and Fraga, writing in Molecular Metabolism in 2021, established that NNMT sits at the crossroads of cellular metabolism and epigenetic regulation: its activity directly affects the methyl economy that governs gene expression and energy metabolism in fat cells