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Musculoskeletal safety signals include cartilage volume loss with repeated intra-articular triamcinolone for knee OA, elevated infection risk around arthroplasty when injections are given close to surgery, and tendon rupture (rare but real)

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5-Amino-1MQ is a small molecule membrane-permeable inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT)