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A study reported that the levels of antioxidants in seminal plasma from infertile men were significantly lower than levels in fertile controls, and it was demonstrated that the levels of ROS produced by spermatozoa were negatively correlated with the quality of sperm in the original semen (Pasqualotto et al., 2000)

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Unlike other forms of cell death such as iron death and apoptosis, copper‑induced cell death has gained increasing recognition as a significant process influencing the development of cardiovascular diseases