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Synthetic HNPs function as histone-chelating agents through selective neutralization of circulating histones (key DAMPs causing endothelial dysfunction), peripheral sequestration of histones to inhibit platelet aggregation, and attenuation of pulmonary leukocyte migration, collectively improving outcomes in experimental sepsis models [94]

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The Journal of Pharmacology and Experimental Therapeutics issued an Expression of Concern in 2021 (PMID: 34551989) for the McCoy et al