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Following the FDA accelerated approval of seladelpar (Livdelzi) for the treatment of #PBC, Palak Trivedi, MD, PhD, Nancy Reau, MD, and Gideon Hirschfield, PhD, MB BChir discussed the evolving ...
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Previous studies performed with amphibian skin peptides, such as temporins, demonstrated that bacteria could still be alive even if AMPs affect the permeability of the bacterial membrane, making it accessible to small molecules (124), strengthening the notion that membrane perturbation is not per se a lethal event