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The only EZH2 inhibitor approved by FDA is Tazemetostat (Tazverik) (Figure 2), used for the treatment of metastatic or locally advanced epithelioid sarcoma (Margueron et al., 2008)

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demonstrated that single nucleotide polymorphisms (SNPs) of the AS3MT gene ought to be considered when determining the therapeutic dose of ATO, and that the urinary primary methylation index (PMI) can be used as a monitoring indicator of ATO-related chronic adverse reactions (AEs) (Zheng et al., 2021)

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