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Together, these examples show that with every use of chemical interventions off-targets for both the chemical and the solvent need to be ruled out for the proper interpretation of the results and mechanistic conclusions (Figure 3)

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Bundles:3+1 E11VEN Glutathione

Pb 2+ exposure impairs NMDA receptor function by interfering with its redox and voltage-dependent regulation, leading to reduced calcium influx critical for LTP and memory formation [67]