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It catalyzes the conversion of phosphatidyl inositol ( 2 ) to phosphatidylinositol ( 3 ), and this PIP3 initiates the localization of AKT to membrane and its subsequent activation by PDK1.ROS accumulation leads to phosphorylation of PI3K on tyrosine residues of a regulatory subunit (p85α) and thereby results in disassembly of it from its catalytic counterpart p110α (85–87)
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