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That is, the large outwardly-directed GSH electrochemical gradient serves to energize the uptake of drugs and other xenobiotics into the cells by an exchange mechanism (Li et al., 1998)

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In a PD mouse model study, it was found that giving berberine orally increases tyrosine hydroxylase activity in Enterococcus faecalis , leading to higher production of l-DOPA, a dopamine precursor