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Perhaps unsurprisingly, patients require doses greater than the recommended daily allowance (RDA) of vitamin C after surgery, and the administration of exogenous vitamin C is associated with better surgical outcomes

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We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig