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In the private healthcare system, 47·8 million measurements were recorded, with a similar gender distribution: 69% female (32·8 M) and 31% male (15 M) (Figure 3A)

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The Key Factors in the Methylation Cycle We will now consider three important causes of interruption to the methylation cycle: Vitamin B12 deficiency Folate deficiency MTHFR mutation Vitamin B12 deficiency If vitamin B12 is deficient, the methyl group cannot be transferred from methylfolate to the methionine cycle