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eLife 11 , e72588 (2022)

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Glossary ABBREVIATIONS ADR adverse drug reaction MIE molecular initiating event TEN toxic epidermal necrolysis SJS Stevens-Johnson syndrome DRESS drug reaction with eosinophilia and systemic symptoms GSH glutathione LC-MS/MS liquid chromatography–tandem mass spectrometry RCS reactive carbonyl species AOP adverse outcome pathway DNCB 2,4-dinitro-1-chlorobenzene GST glutathione-s-transferase SOD superoxide dismutase NAD + /NADH nicotinamide adenine dinucleotide NADP + /NADPH nicotinamide adenine dinucleotide phosphate Keap1 Kelch-like ECH-associated protein Nrf2 Nuclear factor erythroid 2-related factor 2 EpRE/ARE electrophile/antioxidant response element CYP p450 cytochrome p450 enzyme systems NSAIDs nonsteroidal anti-inflammatory drugs AO/ALDH aldehyde oxidases/dehydrogenase NQR NAD(P)H quinone reductase EH epoxide hydrolase UGTs Uridine 5′-diphospho-glucuronosyl transferases SULTs sulfotransferases (NATs) N-acetyl transferases MHC I major histocompatibility complex I MCI 5-chloro-2-methylisothiazol-3-one MDBGN 2-bromo-2-(bromomethyl)glutaronitrile 2-MGN 2-methyl glutaronitrile CD cluster of differentiation NMR nuclear magnetic resonance MAS NMR magic angle spinning nuclear magnetic resonance GLO1 glyoxalase 1 NKT natural killer T cells MS mass spectrometry CF cystic fibrosis ROS reactive oxygen species UPR unfolded protein response ALDH aldehyde dehydrogenase LP lipid peroxidation PUFA polyunsaturated fatty acid HLA human leukocyte antigen APC antigen presenting cell DC dendritic cell DILI drug induced liver injury DHR drug hypersensitivity reaction DAMPS damage associate molecular patterns PAMPS pathogen associated molecular patterns ICOS inducible costimulatory PD1 programmed cell death protein CTLA4 cytotoxic T lymphocyte antigen 4 LAG3 lymphocyte activation antigen 3 VISTA V-domain Ig suppressor of T cell activation IL10 interleukin 10 TNF-α tumor necrosis factor alpha SIRT6 sirtuin 6 ZAP-70 zeta chain of T cell receptor associated protein kinase 70 Lck lymphocyte-specific protein tyrosine kinase Orai1 calcium release-activated calcium channel protein 1 LAT linker of activated T cells TCR T cell receptor AGE advanced glycation endproducts Hsp90 heat shock protein 90 ATPase adenosine triphosphatase YAP yes-associated protein mAbs monoclonal antibodies ALE advanced lipooxidation endproducts HSA human serum albumin HLA human leukocyte antigen IFN-γ interferon gamma Il-1β interleukin 1 beta TCI targeted covalent inhibitors PROTACs proteolysis-targeting chimeras POI protein of interest S N Ar nucleophilic substitution on an aromatic center CAD collisionally activated dissociation Biographies Dr