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To potentially prevent or slow down LA fragmentation by the brush-border enzymes responsible for LA fragmentation, chiral modification of the entire LA sequence to all D amino acids was conducted, which resulted in the generation of LA Analog 6 (A6) by Innovate Biopharmaceuticals, Inc
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While the compound has shown efficacy in animal models, he notes that more research is needed to fully understand the risks and benefits for human use, especially over extended periods
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