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Nonetheless, iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively

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Gram-negative bacteria secrete LPS, which binds to the complex receptor CD4/TLR4 on the surface of immune cells, releasing proinflammatory cytokines and developing inflammatory responses and metabolic disorders, ultimately leading to diseases such as obesity ( 2.2.2 Oxysterols influence AMD development Oxysterols are cholesterol derivatives produced via enzymatic or free radical oxidation associated with oxidative stress, inflammation, and apoptosis (Testa et al., 2018