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Cyclophosphamide, an alkylating agent that blocks DNA replication, together with Docetaxel, an inhibitor of the dynamics of microtubules, essential components of cell division, is the neoadjuvant chemotherapy regimen with the best pCR in patients with TNBC, with a pCR rate of 50%, compared with very low or zero rates in luminal A and type B subtypes

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01Mechanism of action The mechanism of GHK-Cu articulates around three axes: copper chelation, extracellular matrix remodelling, and massive transcriptional modulation