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Since oligodendrocyte function is intimately linked to neighboring glial cells and neuronal activity, in addition to microenvironmental factors, the most promising interventions will likely involve a combinatorial approach (Alizadeh, Dyck et al., 2015, Alizadeh & Karimi-Abdolrezaee, 2016, Ohtomo, Iwata et al., 2018)
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The NNMT Problem and the NAD+ Solution To understand why researchers study 5-Amino-1MQ, one must understand the “Salvage Pathway.” Cells rely on a molecule called NAD+ (Nicotinamide Adenine Dinucleotide) to fuel their mitochondria