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We were taught that after calculating and finding an abnormal AG, which ranges from 8-14, depending on the laboratory calibration and volume status, the next step should be correlating the increment of the gap with the decrement in bicarbonate and considering possible causes of the wide AG

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22 For example, oxygen levels within the TME can vary due to increased metabolic demand from rapidly proliferating tumor cells, resulting in low oxygen tension, known as hypoxia, in tissues