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It may seem counterintuitive, as one might assume exercise could exacerbate the issue, but engaging in low-impact cardio exercises like swimming, brisk walking, and cycling can actually fortify the knee and lessen discomfort

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31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 32–34 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 18–25%