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Human-PBGD (hPBGD) mRNA encapsulated in lipid nanoparticles administered via IV-induced dose-dependent protein expression in mouse hepatocytes and rapidly normalized urine ALA and PBG excretion in ongoing attacks
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To further validate this method we confirmed that both Lyn and IL-1sRII are susceptible to glutathionylation in vitro and provide the first evidence that these proteins undergo glutathionylation in THP-1 cells
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