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Chalcones Chalcones are also termed open-chain flavonoids due to their unclosed C-ring, a single bond between C2-C3

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Importantly, HSV-1 produces the accumulation of Aβ 1–42 and Aβ 1–40 , as well as AβPP reduction in human cultured neuronal cells in vitro , which was related to the up-regulation of β- and γ-secretase components in those cells (Wozniak et al., 2007)