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In NAFLD-induced liver injury, ACN attenuated oxidative stress and inflammation by three independent mechanisms: inhibition of lipogenesis by reducing sterol regulatory element binding protein-1c (SREBP-1c), promotion of lipolysis by induction of PPARα activity, and reduction of oxidative stress (Valenti et al., 2013)

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This discrepancy may be attributed to disease heterogeneity, differences in patient enrollment criteria (e.g., disease stage and progression rate), or genetic factors (37)