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How Vitamin B12 Affects Brain Chemistry and Stress Systems Neurotransmitter production B12, together with folate and B6, is essential for the methylation reactions that produce serotonin, dopamine, norepinephrine, and GABA — the neurotransmitters most directly involved in regulating mood, motivation, calm, and emotional stability
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And in rare cases, a reaction signals something that genuinely needs medical attention