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Discussion The primary aim of this study was to determine whether oral glycine supplementation would correct its deficiency in individuals with severe obesity and to evaluate its impact on the metabolic pathways that are dependent on glycine availability, including the glycine conjugation detoxification pathway, GSH synthesis, and the 1-carbon cycle

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Gut-derived immune activation exacerbates central pathology in stroke and in autoimmune diseases like MS, while there is evidence that dietary interventions and probiotics can also attenuate disease severity and improve functional outcome