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However, the increase in AMPAergic transmission disappeared after 24 h of copper treatment indicating a homeostatic response to increased levels of exogenous copper on a longer timescale (Peters et al., 2011), including increased expression of metal-binding proteins (Durnam & Palmiter, 1981)

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However, there is another gene more directly associated with sulfur intolerance: cystathionine beta-synthase (CBS)