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If either the dose of Tylenol is too high, the detoxification system is impaired for another reason, or there is a baseline depletion of glutathione, then significant oxidative stress will result (via direct toxicity and oxidative damage from NAPQI as well as depletion of the antioxidant defense system)
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To determine whether GSSG-induced TNFα hepatotoxicity is associated with inhibition of the NF-κB signaling pathway, we first examined the effects of H 2 O 2 , BCNU, and diamide treatment on TNFα-stimulated NF-κB activation
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