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The most common complications with piriformis injections are: Joint infection Nerve damage A temporary flare of pain and inflammation in the joint Tendon weakening or rupture Thinning of skin and soft tissue around the injection site Thinning of nearby bone (osteoporosis) Death of nearby bone (osteonecrosis) Whitening or lightening of the skin around the injection site Of these risks, nerve damage and muscle, bone, and soft tissue degradation are the most common