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This finding highlights that PDK inhibition exerts positive regulatory effects in glycolysis via PDHC, allowing M1 macrophages to be polarized toward the M2 phenotype, thus tempering the release of inflammatory mediators ( TCA Remodeling and Lipid Metabolism Disorders It is reported that in hepatocytes under septic condition, multiple TCA cycle-related metabolites, including citrate, cis-aconitate, and succinate, were markedly upregulated, indicating the remodeling of TCA ( via the mitochondrial citrate carrier (CIC), is a key molecule for the generation of energy

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