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Bevorzugte Substituenten sind Ci-C 8 -Alkyl-, Hydroxymethyl-, Hydroxy-, Amino- und Carboxygruppen

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(2006) have presented a newer model for the catalytic reaction in which Glu146 functions as a general base, accepting a proton from zinc-bound water and shuttling the proton to the leaving group facilitating breakdown of the tetrahedral intermediate