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Production of Reactive Oxygen Species in Neuronal Systems Reactive oxygen species (ROS), including superoxide (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH • ), are produced via the leaking of electrons from the mitochondrial respiration chain or through certain enzymatic reactions, such as NADPH oxidase (NOX) and monoamine oxidase (MAO) under physiological conditions (Fig