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Immunocal Protects HT22 Mouse Hippocampal Cells from Toxicity Induced by Overexpression of Amyloid-Beta Peptide (A β 1-42 ) A β 1-42 is the major constituent of senile plaques, which form in the brains of Alzheimer's patients, leading to the hypothesis that increased production of this protein from aberrant processing of amyloid precursor protein is a major contributor to neuronal death and disease pathogenesis [48]