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It participates in two critical enzymatic reactions: the conversion of methylmalonyl-CoA to succinyl-CoA (important for energy production) and the methylation of homocysteine to methionine (crucial for neurotransmitter synthesis and myelin maintenance)
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The R620W PTPN22 variant has also been shown to increase total Treg and naïve Treg subgroups in T1D patients compared to healthy controls, which is counterintuitive in the context of T1D (75)
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