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Click The Image Hypothelamic-Pituitary-Adrenal Axis Chronic stresses, acidosis, pain, hypoglycemia, etc., induce the hypothalamus to release corticotropin releasing hormone (CRH), which acts on the pituitary to cause the release of adrenocorticotropic hormone (ACTH), which acts on the adrenal gland to cause the secretion of cortisol, the major chronic stress hormone

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It’s used for chronic weight management in combination with a reduced-calorie diet and increased physical activity in adults with obesity or overweight