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2 The structure of the intestinal barrier The term “intestinal barrier” emphasizes the barrier function of the intestinal wall which protects organism against invading by bacteria or other microorganisms and potentially toxic components of microorganisms

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The “translational squeeze” — the number of products that begin rodent trials compared to the number that successfully progress from rodent trials to human trials, and from human trials to regulatory approval — is estimated to be greater than 20 to one