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FEMALE INFERTILITY As with male fertility, oxidative stress or reactive oxygen species (ROS) in the female reproductive system, at low levels, is important in the mediation of processes such as hormone signaling, egg maturation, folliculogenesis (follicle growth cycle), fallopian tube function, proper production of hormones from the ovaries, changes in the uterine lining throughout the cycle, various functions throughout pregnancy, and initiation of labour
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We have previously shown that estrogen-induced transcription is triggered by LSD1-catalyzed demethylation of lysine 9 in histone H3 (H3K9), which is activated by the binding of liganded estrogen receptor to the enhancers of target genes 140
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