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J Clin Invest (2004) 113(1):25–7.10.1172/JCI20660 181 BarbourLAMizanoor RahmanSGurevichILeitnerJWFischerSJRoperMDet alIncreased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
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Anti-Inflammatory Effects: IRR activation suppresses local pro-inflammatory cytokine production, reducing the inflammatory response that contributes to tissue damage
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