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SAMe is a methyl donor involved in various methylation reactions in the body, including the synthesis of some neurotransmitters, such as dopamine and serotonin

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A heart-rate increase is expected and measured from 0.3 mg upward — the lean Phase 1 cohort averaged +7.2 bpm at 0.3 mg and +10.0 bpm at 1 mg — so a microdose is not an HR-silent dose in a lean body