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Additionally, maintaining consistent sleep and wake times, avoiding caffeine after 2 p.m., and limiting screen exposure 1–2 hours before bed support natural melatonin production independent of medication effects

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NMDAR are closed at resting membrane potential and open only upon a combination of coincident pre-and post-synaptic events (presynaptic glutamate release, co-agonist release, postsynaptic depolarization), eventually allowing calcium influx and subsequent intracellular signalling leading to the addition or retraction of post-synaptic glutamate receptors