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Other post-translational modification enzymes, such as RAS-converting enzyme 1 or isoprenyl carboxyl methyltransferase may also be potential therapeutic targets to block KRAS membrane localisation, especially phosphodiesterase-δ, which assists the transport of KRAS from the Golgi apparatus to the plasma membrane 155

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Presentation:10x5ml

For instance, a possible translocation of GSH into the nucleus in response to acute oxidative stress has been suggested [62]