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3.3.1 Case study: patient #1 In April 2016, Patient #1 received a diagnosis of PV, accompanied by concerning test results: a JAK2 allele burden of 68%, an unusually elevated hematocrit level at 68%, and a high hemoglobin level of 19 g/dL

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It may influence: Cytokine signaling Immune-cell migration Oxidative stress Apoptosis Macrophage activity Tissue-protective pathways The goal is not necessarily to eliminate inflammation

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