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It is studied within controlled laboratory models examining cyclic AMP accumulation dynamics — cyclic AMP is a second messenger molecule that relays receptor-level binding events into the cell interior — across all three receptor pathways simultaneously, and how tri-receptor co-activation modulates downstream effector protein responses relative to individual receptor stimulation

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In RA, the synovial tissue is the defined by the presence of various pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, IL-12, and IL-23, thus creating an inflammatory microenvironment causing the damage of the joints [188]