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CSD has been demonstrated to activate the trigeminovascular system (TVS) both centrally and peripherally by exposing the dura to inflammatory molecules, indicating that susceptibility to CSD may contribute to the initiation of migraine attacks (26, 27)

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Peptides capable of binding copper ions have become an area of research due to their potential role in: Cellular signaling mechanisms Peptide–metal interactions Structural and biochemical modeling Tissue and extracellular matrix research models GHK-Cu is one of the most widely referenced copper peptides in scientific literature, making it a frequent subject of in vitro and ex vivo research