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The singular randomized, double-blind, placebo-controlled clinical trial by Watanabe et al., conducted in 30 healthy Filipino women aged 30–50 years has provided virginal evidence favoring efficacy of topical GSSG 2% lotion (applied twice daily for 10 weeks) in producing temporary skin whitening [12]

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When taking other medications, it is important to understand the ingredients to reduce the risk of drug interactions and adverse events