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However, we did observe that ML226 drove a memory T cell phenotype, as after 11 days of treatment, there was an increase in the CCR7 high CD45RO high central memory T cell population (T CM ), and a corresponding decrease in the CCR7 low CD45RO high effector memory T cell population (T EM
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More interestingly, in a pan-cancer cohort treated with anti-PD-1 immunotherapy 36 , high FGL1 expression was linked to poor prognosis, whereas elevated TRIM21 or IRF1 expression correlated with favorable outcomes, aligning with our above observations (Supplementary Fig
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