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In challenge infections using WT UTI89 and UTI89Δ hlyA strains in naïve, resolved and sensitized mice, we observed that Δ hlyA infection, which does not activate caspase-1-mediated pyroptotic cell death, showed significantly increased bacterial burdens in sensitized mice compared with WT mice, whereas no differences were observed in naïve and resolved mice (Fig

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[DOI] [PubMed] [Google Scholar] 2.Clayton J.A