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Data was extracted from a medical literature review (pubmed.ncbi.nlm.nih.gov) conducted up to 5 th of March 2025, using the keywords ‘neuroprotection, MS, neurodegeneration, molecular mechanisms, microglia, astrocyte, remyelination.’ We first refer to the principles of neuroprotection through preventing peripheral-driven inflammation, and then outline CNS inflammation and mechanisms of neuronal injury including neuronal death, remyelination and axonal regeneration in MS

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