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Supplements including vitamin C, alpha-lipoic acid, or N-acetyl cysteine (NAC), for instance, can help the body generate and recycle glutathione
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The inhibition or reversal of tachyphylaxis and fade by both ascorbate [70,71,72,73,74,75] and opioids [65,76,77] is mediated by increased cGMP production and concomitant inhibition of the G protein-mediated phosphorylation that down-regulates the receptor
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