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intraperitoneally [IP]) dramatically reduced marble-burying behaviour in male Institute of Cancer Research mice without influencing locomotor activity, based on a preliminary study of the medication in an OCD animal study

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Figure 3c shows that surface-targeted LaccID enriches N-cadherin but not calreticulin, while surface-targeted APEX2 and HRP enrich both markers because of (1) substantial pools of APEX2 and HRP in the ER lumen because of their imperfect targeting to the cell surface, and (2) high activity of APEX2 and HRP in the ER compartment