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From Uric Acid Metabolism to Gouty Inflammation: Model Strategies for Preclinical Research

doi: 10.1016/j.bbrc.2021.02.126 80 GuoSZhaoWZhangWLiSTengGLiuL

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The elevated SOD2 activity is achieved as a result of an upregulation of sirtuin 3 (SIRT3), one member of a family of epigenetic enzymes located primarily in the mitochondrial matrix that regulates a variety of metabolic processes (104, 105)

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