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Most patients describe the sensation as: A quick pinching feeling Mild pressure Slight stinging lasting only a few seconds Minor soreness afterwards The discomfort is usually much less than people expect

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Because MOTS-c is naturally produced in response to exercise, and because it activates the same AMPK and mitochondrial biogenesis pathways that exercise training upregulates, combining exogenous MOTS-c with a structured exercise program creates a reinforcing signal that operates through the same biological channels